1428482-14-7

Upstream product

• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 159847-81-1 methyl 2-AMINO-5-CYANOBENZOATE 
• 1031927-03-3 methyl 5-bromo-2-cyanobenzoate 

Downstream Products

• 1428482-16-9 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2,4'-dicarboxylic acid 4'-tert-butyl ester 2-methyl ester 
• 1428482-17-0 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2,4'-dicarboxylic acid 2-methyl ester 
• 1428480-62-9 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-5'-trifluoromethyl-biphenyl-2-carboxylic acid 
• 1428480-73-2 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid 
• 1428481-04-2 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-nitro-biphenyl-2-carboxylic acid 
• 1428481-06-4 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid 
• 1428481-07-5 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-4'-(3-dimethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid 
• 1428481-35-9 2-(2-carbamoyl-pyridin-3-yl)-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid 
• 1428482-09-0 4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid 
• 1428482-19-2 C₂₄H₁₃Cl₂F₃N₂O₄S 
• 1440950-44-6 C₂₃H₁₄Cl₂N₂O₄S 
• 1428482-22-7 C₃₁H₃₁Cl₂N₃O₃S 
• 1428482-23-8 C₂₉H₂₇Cl₂N₃O₃S 
• 1428482-15-8 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

EIF4E INHIBITORS AND USES THEREOF

The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.

BENZOIC ACID DERIVATIVES

There are disclosed are compounds of the formula: wherein R1 and R2 are as disclosed herein, which are eIF4E inhibitors useful in the treatment of cancers. Also disclosed are compositions comprising the compounds, as well as methods of treating cancer using the compounds.