142851-03-4

Basic information

• Product Name: Ethyl N-Boc-piperidine-4-carboxylate
• Synonyms: N-BOC-4-CARBETHOXY PIPERIDINE;PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-ETHYL ESTER;1-BOC-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;1-TERT-BUTYL 4-ETHYL 1,4-PIPERIDINEDICARBOXYLATE;1-TERT-BUTYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE;1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE;ETHYL N-BOC-ISONIPECOTATE;ETHYL N-BOC-PIPERIDIN-4-YL CARBOXYLATE
• CAS NO: 142851-03-4
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.33
• Product Categories: Amino Acids and Derivatives;Heterocycles;Esters;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 142851-03-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 120-135 °C0.5 mm Hg
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.046 g/mL at 25 °C
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: n20/D 1.458
• Storage Temp.: 0-10°C
• Solubility: Chloroform, Ethyl Acetate
• PKA: -2.23±0.40(Predicted)
• CAS DataBase Reference: Ethyl N-Boc-piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl N-Boc-piperidine-4-carboxylate(142851-03-4)
• EPA Substance Registry System: Ethyl N-Boc-piperidine-4-carboxylate(142851-03-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 142851-03-4(Hazardous Substances Data)

Usage

Chemical Properties

Liquid

Uses

Different sources of media describe the Uses of 142851-03-4 differently. You can refer to the following data:
1. Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.
2. Substrate used in a palladium-catalyzed α-arylation of esters with heterocyclic bromides and chlorides leading to, for example, 4-pyridylpiperidinyl esters.

InChI:InChI=1/C13H23NO4/c1-5-13(10(15)16)6-8-14(9-7-13)11(17)18-12(2,3)4/h5-9H2,1-4H3,(H,15,16)

Downstream Products

• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 191805-27-3 ethyl 4-(4-oxo-4-phenylbutyl)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylate 
• 1025986-88-2 4-(4-but-2-ynyloxy-phenylsulfanyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 213013-98-0 4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester