1428522-68-2Relevant articles and documents
A facile synthesis of tetracyclic benzo-pyridonaphthyridines by domino reaction
Basetti, Vishnu,Pallepati, Rangarao,Hosahalli, Subramanya,Potluri, Vijay
, p. 2014 - 2017 (2013/04/10)
A novel methodology for the synthesis of tetracyclic benzo- pyridonaphthyridines, forming a C-C and a C-N bond in concentrated sulfuric acid at 70 °C in a one-pot is reported. The key substrates (9a-m) are prepared by reacting 2-chloro-6-(4-fluorophenyl)-4-methylnicotinenitrile (7) with various anilines followed by dimethylformamide dimethylacetal. The domino reaction is initiated by the protonation of the b-carbon of the enamine group in 9a-m and terminated by the elimination of dimethylamine.