1428522-78-4

Basic information

• Product Name: 2-(4-chlorophenoxy)-6-(4-fluorophenyl)-4-methylnicotinonitrile
• Synonyms: 2-(4-chlorophenoxy)-6-(4-fluorophenyl)-4-methylnicotinonitrile
• CAS NO: 1428522-78-4
• Molecular Weight: 338.768
• Mol File: 1428522-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenoxy)-6-(4-fluorophenyl)-4-methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenoxy)-6-(4-fluorophenyl)-4-methylnicotinonitrile(1428522-78-4)
• EPA Substance Registry System: 2-(4-chlorophenoxy)-6-(4-fluorophenyl)-4-methylnicotinonitrile(1428522-78-4)

Safety Data

• Hazardous Substances Data: 1428522-78-4(Hazardous Substances Data)

Upstream product

• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 
• 943117-82-6 2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 1428522-86-4 8-(4-chlorophenoxy)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one 

Relevant articles and documents

A facile synthesis of tetracyclic benzo-pyridonaphthyridines by domino reaction

A novel methodology for the synthesis of tetracyclic benzo- pyridonaphthyridines, forming a C-C and a C-N bond in concentrated sulfuric acid at 70 °C in a one-pot is reported. The key substrates (9a-m) are prepared by reacting 2-chloro-6-(4-fluorophenyl)-4-methylnicotinenitrile (7) with various anilines followed by dimethylformamide dimethylacetal. The domino reaction is initiated by the protonation of the b-carbon of the enamine group in 9a-m and terminated by the elimination of dimethylamine.