1428548-93-9

Upstream product

• 1428548-90-6 2,5-bis(p-tolylthio)pyrazine 
• 106-45-6 para-thiocresol 

Downstream Products

• 1428549-15-8 diethyl 2-(5-tosylpyrazin-2-yl)malonate 
• 1428549-14-7 N-methyl-N-(pyridin-4-yl)-5-tosylpyrazin-2-amine 
• 1428549-11-4 2-(pyridin-2-yloxy)-5-tosylpyrazine 
• 1428549-13-6 N-(pyridin-4-yl)-5-tosylpyrazin-2-amine 

Relevant academic research and scientific papers

2,5-Bis-(sulfonyl)pyrazines as unprecedented building blocks and their SNAr reactions

Previously unknown 2,5-bis-sulfonylpyrazines are prepared and their SNAr reactions are investigated. When 2 equiv of thiols are employed, the corresponding bis-thiopyrazines are obtained exclusively. However, phenols or alkoxides gave rise to only the corresponding mono-substituted aryloxy- or alkoxy-sulfonylpyrazines in excellent yields. A carbon nucleophile prepared by treating malonate with NaH also produced the corresponding mono- sulfonylpyrazines. Aliphatic amines and anilines only provided the mono-anilino-sulfonylpyrazines in poor to moderate yields.