142855-79-6

Basic information

• Product Name: 1H-Azepine-1-aceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexahydro-2-oxo-,(3S)-(9CI)
• Synonyms: 1H-Azepine-1-aceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexahydro-2-oxo-,(3S)-(9CI);(S)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-acetic acid;(S)-2-(3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-oxoazepan-1-yl)acetic acid;Fmoc-[3S]-3-amino-1-carboxymethylcaprolactame98+%
• CAS NO: 142855-79-6
• Molecular Formula: C₂₃H₂₄N₂O₅
• Molecular Weight: 408.45
• Product Categories: FMOC
• Mol File: 142855-79-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 692.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: Store at 0-5°C
• PKA: 3.73±0.10(Predicted)
• CAS DataBase Reference: 1H-Azepine-1-aceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexahydro-2-oxo-,(3S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Azepine-1-aceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexahydro-2-oxo-,(3S)-(9CI)(142855-79-6)
• EPA Substance Registry System: 1H-Azepine-1-aceticacid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexahydro-2-oxo-,(3S)-(9CI)(142855-79-6)

Safety Data

• Hazardous Substances Data: 142855-79-6(Hazardous Substances Data)

Usage

Uses

Fmoc-(3S)-3-amino-1-carboxymethylcaprolactame is used in the synthesis of unsubstituted piperazinone-based transition state factor Xa inhibitors. It is also used to prepare peptidomimetics containing Freidinger lactams as STAT3 inhibitors.

Downstream Products

• 1147514-20-2 C₅₄H₅₃N₅O₆ 
• 549506-83-4 N-[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide 
• 174960-90-8 (3S)-hexahydro-2-oxo-3-[[(phenylmethyl)sulfonyl]amino]-1H-azepine-1-acetic acid 
• 174960-89-5 ((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetic acid benzyl ester 
• 93961-03-6 (S)-3-Amino-2-oxo-hexahydro-1H-azepine-1-acetic acid, phenylmethyl ester 

Relevant articles and documents

PEPTIDE DERIVATIVES

The invention concerns pharmaceutically useful peptide derivatives of the formula (I), P-AA I -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -AA 7 -AA 8 -Q, in which P, AA 1, AA 2, AA 3 , AA 4, AA 5, AA 6, AA 7, AA 8, and Q have the various meanings defined herein and their pharmaceutically accentable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.