1428550-07-5

Upstream product

• 1372628-19-7 dimethyl 2-(N-(1-(2-chlorophenyl)-3-phenylprop-2-ynyl)-4-methylphenylsulfonamido)maleate 
• 1428549-79-4 dimethyl 2-(N-(1-(2-chlorophenyl)-3-phenylprop-2-ynyl)-4-methylphenylsulfonamido)maleate 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant academic research and scientific papers

One-pot synthesis of pyridines from 3-aza-1,5-enynes

Efficient one-pot transformation of 3-aza-1,5-enynes to poly-substituted pyridines in good to excellent yields has been developed. This reaction involved cyclization of 3-aza-enynes and elimination of sulfinyl acids steps.

Cyclization and N-iodosuccinimide-induced electrophilic iodocyclization of 3-aza-1,5-enynes to synthesize 1,2-dihydropyridines and 3-iodo-1,2- dihydropyridines

Metal-free cyclization and N-iodosuccinimide-induced electrophilic iodocyclization of readily available 3-aza-1,5-enynes have been developed. The reactions selectively give 1,2-dihydropyridines and 3-iodo-1,2-dihydropyridines involving an aza-Claisen rearrangement and a 6π-electrocyclization step. Furthermore, the reaction could be carried out in 10 g scale for the synthesis of 1,2-dihydropyridines.