1428550-35-9

Upstream product

• 1428549-97-6 N-(3-(4-chlorophenyl)-1-phenylprop-2-yn-1-yl)-4-methylbenzenesulfonamide 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 1428549-87-4 dimethyl 2-(N-(3-(4-chlorophenyl)-1-phenylprop-2-ynyl)-4-methylphenylsulfonamido)maleate 

Relevant academic research and scientific papers

Cyclization and N-iodosuccinimide-induced electrophilic iodocyclization of 3-aza-1,5-enynes to synthesize 1,2-dihydropyridines and 3-iodo-1,2- dihydropyridines

Metal-free cyclization and N-iodosuccinimide-induced electrophilic iodocyclization of readily available 3-aza-1,5-enynes have been developed. The reactions selectively give 1,2-dihydropyridines and 3-iodo-1,2-dihydropyridines involving an aza-Claisen rearrangement and a 6π-electrocyclization step. Furthermore, the reaction could be carried out in 10 g scale for the synthesis of 1,2-dihydropyridines.