1428553-39-2Relevant articles and documents
A BH3 masked H-phosphonate for coupling in oligonucleotide synthesis
Huang, Jinyu,Lu, Wei,Xi, Zhen
supporting information, p. 2183 - 2186 (2013/05/08)
A method of masking 3′-H-phosphonate group for the solution-phase synthesis of ribonucleotide by H-phosphonate approach was described. The phosphonic acid group was masked by bis-(2-cyanoethyl) boranophosphate during the reactions. After a successive demasking treatment by triethylamine, trityl cation, and triethylamine, the triethylammonium 3′-H-phosphonate nucleotide can be obtained efficiently ready for the coupling cycle in synthesis of oligonucleotide.