1428587-08-9

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 205999-88-8 5-methoxycarbonyl-6-methyl-4-(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1446133-80-7 C₁₉H₁₇BrClN₃O₂*ClH 
• 1446133-82-9 C₁₉H₁₇ClN₄O₅*ClH 
• 1446133-84-1 C₁₉H₁₆BrClFN₃O₂*ClH 
• 1446133-88-5 C₂₀H₁₇ClF₃N₃O₂S*ClH 
• 1446133-90-9 C₁₉H₁₇BrClN₃O₂*ClH 
• 1446133-92-1 C₁₉H₁₇Cl₂N₃O₃*ClH 
• 1446133-94-3 6-(4-chlorophenyl)-2-(2,4-dimethoxybenzylamino)-5-(methoxycarbonyl)-4-methyl-3,6-dihydropyrimidin-1-ium chloride 

Relevant academic research and scientific papers

Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate Against Anopheles arabiensis Mosquito

Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesized by three-step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.

Synthesis and Antitubercular Activity of 2-(substituted phenyl/benzyl-amino)-6-(4-chlorophenyl)-5-(methoxycarbonyl)-4-methyl-3,6-dihydropyrimidin-1-ium Chlorides

A series of 2-(substituted phenyl/benzyl-amino)-6-(4-chlorophenyl)-5-(methoxycarbonyl)-4-methyl-3,6-dihydropyrimidin-1-ium chlorides 7-13 and 15 was synthesized in their hydrochloride salt form. The title compounds were characterized by FT-IR, NMR (1H and 13C) and elemental analysis. They were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv, multidrug resistance tuberculosis and extensively drug resistance tuberculosis by agar diffusion method and tested for the cytotoxic action on peripheral blood mononuclear cells by MTT assay. Among all the tested compounds in the series, compounds 7 and 11 emerged as promising antitubercular agents at 16μg/mL against multidrug resistance tuberculosis and over 64μg/mL against extensively drug resistance tuberculosis. The conformational features and supramolecular assembly of the promising compounds 7 and 11 were determined by single crystal X-ray study.