1428646-29-0Relevant academic research and scientific papers
Design and synthesis of new 7,8-dimethoxy-α-naphthoflavones as CYP1A1 inhibitors
Cui, Jia-Hua,Hu, Dagula,Zhang, Xu,Jing, Zheng,Ding, Jing,Wang, Ru-Bing,Li, Shao-Shun
, p. 215 - 218 (2013/06/26)
The flavonoids as inhibitors of CYP1A1 exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents. A series of novel 7,8-dimethoxy-α-naphthoflavones as the substrate analogs were designed and prepared. The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1A1 than the lead compound α-naphthoflavone. Among the tested ones, 3h showed the most potent inhibitory effects.
