1428646-97-2Relevant academic research and scientific papers
A novel three-component [5 + 1] heterocyclization leading to 2-azafluorenone synthesis and its polyfunctionalizations
Li, Ying,Fan, Wei,Xu, Hai-Wei,Jiang, Bo,Wang, Shu-Liang,Tu, Shu-Jiang
supporting information, p. 2417 - 2420 (2013/06/05)
An efficient methodology for the synthesis of new and highly functionalized 2-azafluorenones via a three-component domino reaction involving C1-aryl acylation, C3-thiolation, and C4-cyanation has been developed. This domino reaction enables successful assembly of three new sigma bonds including a C-S bond and a C-N bond in a one-pot operation. Features of this strategy include the mild condition, convenient one-pot operation, and short reaction periods (15-30 min). The Royal Society of Chemistry 2013.
