1428649-07-3

Upstream product

• 1403578-92-6 9-bromo-1'-(4-methoxybenzyl)-2H-spiro[benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin]-6(4H)-imine 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 1428649-08-4 N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine 
• 1428649-13-1 C₅₈H₆₉BrN₈O₁₁S₂ 

Relevant academic research and scientific papers

Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182

To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives. In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182.