1428649-40-4

Upstream product

• 50-89-5 thymidine 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 291525-17-2 3′,5′-bis-O-(tert-butyldimethylsilyl)-5-bromomethyl-2'-deoxyuridine 
• 823790-97-2 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(azidomethyl)-2'-deoxyuridine 
• 1428649-29-9 3',5'-bis-O-(tert-butyldimethylsilyl)-5-{[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]methyl}-2'-deoxyuridine 

Relevant academic research and scientific papers

Microwave-assisted click chemistry for nucleoside functionalization: Useful derivatives for analytical and biological applications

A series of novel 5-(1,2,3-triazolyl)-2′-deoxyuridines were synthesized using a simple and convenient one-step synthetic procedure via the Huisgen reaction. The key step in these syntheses is a click reaction at the C-5 position under solvent free microwave irradiation and CuI as a catalyst. 5-Azidomethyl-2′-deoxyuridine was synthesized from thymidine and its click reactions with several alkynes provided triazole derivatives in good yields. The synthesized compounds showed only marginal antiviral activities [against human rhinovirus (HRV), hepatitis C virus (HCV) and HIV] and antibacterial activities against a series of Gram positive and Gram negative bacteria. Evaluation of fluorescence properties of pyrene-modified and EPR studies of nitroxyl spin-labeled deoxyuridines demonstrate the applicability of these compounds as valuable analytical tools. Georg Thieme Verlag Stuttgart - New York.