1428654-86-7

Basic information

• Product Name: (1S,2S,2'S,3'aS,5R)-2'-[4-(2-methyl-4-methoxyphenyl)[1,2,3]triazol-1-ylmethyl]-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one
• Synonyms: (1S,2S,2'S,3'aS,5R)-2'-[4-(2-methyl-4-methoxyphenyl)[1,2,3]triazol-1-ylmethyl]-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one
• CAS NO: 1428654-86-7
• Molecular Weight: 467.611
• Mol File: 1428654-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2S,2'S,3'aS,5R)-2'-[4-(2-methyl-4-methoxyphenyl)[1,2,3]triazol-1-ylmethyl]-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,2'S,3'aS,5R)-2'-[4-(2-methyl-4-methoxyphenyl)[1,2,3]triazol-1-ylmethyl]-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one(1428654-86-7)
• EPA Substance Registry System: (1S,2S,2'S,3'aS,5R)-2'-[4-(2-methyl-4-methoxyphenyl)[1,2,3]triazol-1-ylmethyl]-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one(1428654-86-7)

Safety Data

• Hazardous Substances Data: 1428654-86-7(Hazardous Substances Data)

Upstream product

• 1428654-99-2 (1S,2S,2'S,3'aS,5R)-2'-(bromomethyl)-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one 
• 188858-92-6 6-isopropyl-4,9-dimethyl-3-oxo-1,4-diazaspiro[4.5]dec-1-ene 1-oxide 
• 1428655-00-8 (1S,2S,2'S,3'aS,5R)-2'-(azidomethyl)-2-isopropyl-5,5'-dimethyl-3',3'a-dihydro-2'H-spiro[cyclohexane-1,6'-imidazo[1,5-b]isoxazol]-4'(5'H)-one 
• 74331-69-4 1-ethynyl-4-methoxy-2-methylbenzene 

Relevant articles and documents

Stereoselective synthesis of 1,2,3-triazolyl-functionalized isoxazolidines, via two consecutive 1,3-dipolar cycloadditions, as precursors of unnatural amino acids

1,3-Dipolar cycloaddition of a (-)-menthone-derived nitrone to allyl bromide under microwave irradiation afforded, stereoselectively, the corresponding chiral isoxazolidine in 98% yield. After substitution of the bromine atom by an azide group (98% yield), another 1,3-cycloaddition with various alkynes led to a series of 1,2,3-triazolyl-functionalized isoxazolidines (85% yield). Removal of the chiral auxiliary under acid-catalysis appeared to be a limiting step toward 5-substituted isoxazolidines, which were isolated in modest yields. For a general and reliable access to 5-(triazolyl)methyl- substituted isoxazolidines, which are new compounds and valuable precursors of unnatural amino acids, performing the CuAAC cycloaddition as the final step is recommended.