14287-95-7Relevant articles and documents
Using dialkyl amide: Via forming hydrophobic deep eutectic solvents to separate citric acid from fermentation broth
Liu, Lijuan,Wei, Qifeng,Zhou, Yong,Ren, Xiulian
, p. 2526 - 2533 (2020)
Nowadays, developing appropriate technology is one of the biggest challenges for society to reduce environmental impact. In this research, to avoid the traditional calcium salt method which produces a large amount of waste gypsum residue, a new way of separating citric acid from fermentation broth was developed by forming hydrophobic deep eutectic solvents (DESs), in which amide and citric acid were used as the hydrogen bond acceptor and donor respectively when amide was in contact with the fermentation broth containing citric acid. Among these amides, C10H21NO was found to be an efficient hydrogen bond acceptor forming hydrophobic DESs with the citric acid based on the molecular size and shape and has the largest hydrophobic equilibrium constant of 3.14. The hydrophobic DES formation mechanism was studied by analyzing the chemical bonds using FT-IR and quantum chemical (QC) calculations. C10H21NO was regenerated by elevating the temperature of the hydrophobic DESs. The regenerated C10H21NO exhibited good recycling properties with no obvious reduction of the ability to form hydrophobic DESs. This effective way of obtaining high-quality citric acids provides new ideas for the separation of other carboxylic acids.
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Ogata et al.
, p. 3425 (1968)
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Catalyst-free amidation of aldehyde with amine under mild conditions
Yang, Hongyin,Hu, Wenjian,Deng, Shengjue,Wu, Tiantian,Cen, Haiman,Chen, Yiping,Zhang, Dela,Wang, Bo
supporting information, p. 5912 - 5915 (2015/08/11)
A highly efficient, catalyst-free and one-pot procedure for the direct synthesis of amides from aldehydes and amines under mild conditions has been developed. Both aliphatic and aromatic aldehydes with primary or secondary amines are successfully converted to the corresponding amides, and it is observed that reactions can proceed in either aqueous or organic media.