1428772-52-4Relevant academic research and scientific papers
Solution-phase parallel synthesis of a multisubstituted cyclic imidate library
Mehta, Saurabh,Waldo, Jesse P.,Neuenswander, Benjamin,Lushington, Gerald H.,Larock, Richard C.
supporting information, p. 247 - 254 (2013/07/05)
The solution-phase parallel synthesis of a diverse 71-member library of multisubstituted cyclic imidates is described. The key intermediates, 3-iodomethylene-containing cyclic imidates, are readily prepared in good to excellent yields by the palladium/copper-catalyzed cross-coupling of various o-iodobenzamides and terminal alkynes, followed by electrophilic cyclization with I2. These cyclic imidates were further functionalized by palladium-catalyzed Suzuki-Miyaura, Sonogashira, carbonylative amidation, and Heck chemistry using sublibraries of commercially available building blocks.
