142878-12-4

Basic information

• Product Name: U-73343
• Synonyms: 1-[6-((17BETA-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL]-2,5-PYRROLIDINEDIONE;U-73343;1-[6-[((17β)-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione;3-Methoxy-17-[6-(2,5-dioxopyrrolidin-1-yl)hexylamino]estra-1,3,5(10)-triene
• CAS NO: 142878-12-4
• Molecular Formula: C29H42N2O3
• Molecular Weight: 466.66
• Product Categories: APIS
• Mol File: 142878-12-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 641.5°C at 760 mmHg
• Flash Point: 341.8°C
• Appearance: white/powder
• Density: 1.15g/cm³
• Vapor Pressure: 2.37E-16mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: +15C to +30C
• Solubility: ethanol: 0.93 mg/mL
• PKA: 10.68±0.40(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Dried films prepared from chloroform solution are stable for at least 1 month at -20°. It is preferable to dissolve U-73343 immediately before use if at all possible. Use caution and retest potency if attempting.
• CAS DataBase Reference: U-73343(CAS DataBase Reference)
• NIST Chemistry Reference: U-73343(142878-12-4)
• EPA Substance Registry System: U-73343(142878-12-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 142878-12-4(Hazardous Substances Data)

Usage

Description

U-73343 is a cell-permeable analog of U-73122, which acts as a very weak inhibitor of phospholipase C. It is primarily used as a negative control in various applications due to its inactive structural analog nature.

Uses

Used in Research Applications:
U-73343 is used as a negative control for phospholipase C inhibitor U-73122 (Cat. No. 10-1061) for research purposes. It helps in understanding the effects of phospholipase C inhibition and serves as a reference point in experiments.
Used in Pharmaceutical Industry:
U-73343 is used as a reference compound in the development of new drugs targeting phospholipase C. Its inactive nature allows researchers to compare the effects of active compounds and better understand their mechanisms of action.
Used in Cell Biology:
U-73343 is used in cell biology to study the role of phospholipase C in cellular processes. Its cell permeable property allows it to be used in various cell-based assays and experiments.
Used in Biochemical Assays:
U-73343 is used in biochemical assays to determine the activity of phospholipase C in different samples. As a weak inhibitor, it helps researchers to establish a baseline for comparison with more potent inhibitors.
Used in Drug Discovery:
U-73343 is used in drug discovery to identify potential drug candidates that can inhibit phospholipase C more effectively. Its inactive nature serves as a starting point for the development of new and improved inhibitors.

Biochem/physiol Actions

Cell permeable: yes

References

1) Bleasdale?et al. (1990),?Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther.,?255?756 2) Morley?et al. (1992),?A new, nongenomic estrogen action: the rapid release of intracellular calcium; Endocrinology,131?1305 3) Muto?et al. (1997),?The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell; J. Pharmacol. Exp. Ther.,?282?1379

InChI:InChI=1/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1