1428867-83-7Relevant academic research and scientific papers
Enantioselective synthesis of 3,4-dihydropyran derivatives via a Michael addition reaction catalysed by chiral pybox-diph-Zn(ii) complex
Ray, Sumit K.,Rout, Subhrajit,Singh, Vinod K.
supporting information, p. 2412 - 2416 (2013/06/05)
An enantioselective Michael addition of cyclic 1,3-dicarbonyls to 2-enoylpyridine N-oxides catalyzed by a chiral pybox-diph-Zn(ii) complex has been developed. The corresponding Michael adducts have been obtained in high yields with up to >99% ee. The Michael adduct has been transformed to biologically active 2,4-disubstituted hexahydroquinoline. A plausible transition-state model has been proposed to explain the stereochemical outcome of the reaction. The Royal Society of Chemistry 2013.
