1428871-72-0

Upstream product

• 76626-08-9 1-(4-fluorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Facile and straightforward synthesis of the racemic version of 2-amino-4H-chromene-3-carbonitriles using K2HPO4 as an eco-friendly base

A simple and facile two-step synthetic route has been developed for the preparation of 2-amino-4H-chromenes via chalcone intermediate under an ambient condition, along with the crystallographic analysis of the racemic mixture so obtained. The crystal orientation can be very useful for generic drug development in future. The described non-hazardous optimized methodology also provides an alternative simple route to prepare functionalized 2-amino-4H-chromenes of biological interest.

An unusual and facile N-hetero cyclisation of 2-amino-4-(2-oxo-2-arylethyl)-4H-chromene-3-carbonitrile derivatives using hypervalent iodine in alcohol under ambient condition

A very important functionalized benzopyran moiety has been further functionalized along with an unusual N-heterocyclic ring formation in a single step under ambient condition in room temperature under the influence of hypervalent iodine to produce a structurally interesting motif which can have some interesting biological properties having a similar but modified structure as that of bio-active chromene moieties.

Selective synthesis of cyano-functionalized 2-aryl-4 h -chromenes and 2-amino-4 H -chromene-3-carbonitriles by catalyst-tuned reactions of 2-hydroxychalcones with 2-substituted acetonitriles

A selective synthesis of 4H-chromenes by the reactions of 2-hydroxychalcone derivatives with acetonitriles substituted with electron-withdrawing groups is described. Under catalyst-free conditions, the reactions give cyano-functionalized 2-aryl-4H-chromenes, whereas in the presence of sodium bicarbonate, 2-amino-4H-chromene-3-carbonitriles are obtained in excellent yields. Georg Thieme Verlag Stuttgart New York.