1428872-80-3Relevant academic research and scientific papers
A copper-catalyzed synthesis of 3-aroylindoles via a sp3 C-H bond activation followed by C-C and C-O bond formation
Gogoi, Anupal,Guin, Srimanta,Rout, Saroj Kumar,Patel, Bhisma K.
supporting information, p. 1802 - 1805 (2013/06/04)
An efficient Cu(I)-catalyzed synthesis of 3-aroylindoles has been achieved from o-alkynylated N,N-dimethylamines via a sp3 C-H bond activation α to the nitrogen atom followed by an intramolecular nucleophilic attack with the alkyne using an aqueous solution of tert-butyl hydroperoxide (TBHP) as the oxidant. In this tandem catalytic synthesis of 3-aroylindoles both C-C and C-O bonds are installed at the expense of two sp3 C-H bond cleavages.
