1428882-52-3

Upstream product

• 1428882-60-3 N-(2-iodobenzyl)-3,4-dimethylaniline 
• 126801-53-4 N'-((E)-3-(4-methoxyphenyl)allylidene)-4-methylbenzenesulfonohydrazide 

Relevant academic research and scientific papers

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.