1428885-36-2

Upstream product

• 13910-79-7 2-(3-methylphenyl)acetyl chloride 
• 108-94-1 cyclohexanone 
• 53627-10-4 1-chlorocyclohexane-1-carbaldehyde 
• 1428885-17-9 (RS)-1-(15-methoxy-7-thia-14-azadispiro[5.1.58.26]pentadecan-14-yl)-2-(3-methylphenyl)ethan-1-one 

Relevant academic research and scientific papers

Synthesis of tricyclic lactams from heterocyclic imines

Starting from different heterocyclic imines, a large number of annulated tricyclic lactams were prepared in a two-step synthesis. First, methoxyamides with a phenyl ring in or β-position were 7generated. Finally, these substrates were converted to valero- and caprolactams, respectively, via intramolecular Friedel-Crafts cyclization in the presence of a Lewis acid. Additionally, effects of substituent groups at the phenyl ring in the electrophilic aromatic substitution were investigated.