142890-17-3

Basic information

• Product Name: Propanedioic acid, [5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-pyrrolidinylidene]-, diethyl ester, (R)-
• CAS NO: 142890-17-3
• Molecular Formula: C28H37NO5Si
• Molecular Weight: 495.691
• Mol File: 142890-17-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-pyrrolidinylidene]-, diethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-pyrrolidinylidene]-, diethyl ester, (R)-(142890-17-3)
• EPA Substance Registry System: Propanedioic acid, [5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-pyrrolidinylidene]-, diethyl ester, (R)-(142890-17-3)

Safety Data

• Hazardous Substances Data: 142890-17-3(Hazardous Substances Data)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 
• 138629-44-4 (R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-one 
• 685-87-0 Diethyl 2-bromomalonate 
• 142890-14-0 (R)-5-(tert-butyldiphenylsiloxy)methylpyrrolidin-2-thione 

Downstream Products

• 142890-21-9 (R)-2-(5-p-toluenesulfonyloxymethylpyrrolidin-2-ylidene)malonic acid diethyl ester 

Relevant articles and documents

Synthetic studies of carzinophilin. Part 1: Synthesis of 2-methylidene-1-azabicyclo[3.1.0]hexane systems related to carzinophilin

Synthesis of the model compounds of carzinophilin carrying 2-methylidene-1-aza-bicyclo[3.1.0]hexane systems was achieved. Formation of malonylidenes or N-acyl-glycinylidenepyrrolidines was carried out by utilizing Eschenmoser's sulfide contraction or Herdeis's condensation between the 2-methylthio-Δ1-pyrrolone derivatives and ethyl nitroacetate, respectively. The 1-azabicyclo-[3.1.0]hexane systems were constructed by base-promoted aziridine formation.