1428964-53-7

Basic information

• Product Name: C₁₇H₂₁NO₃PS₂^(1-)*Na⁽¹⁺⁾
• CAS NO: 1428964-53-7
• Molecular Weight: 405.454
• Mol File: 1428964-53-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₁NO₃PS₂^(1-)*Na⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₁NO₃PS₂^(1-)*Na⁽¹⁺⁾(1428964-53-7)
• EPA Substance Registry System: C₁₇H₂₁NO₃PS₂^(1-)*Na⁽¹⁺⁾(1428964-53-7)

Safety Data

• Hazardous Substances Data: 1428964-53-7(Hazardous Substances Data)

Upstream product

• 107-08-4 1-iodo-propane 
• 79467-22-4 (2-((2-(aminomethyl)phenyl)thio)phenyl)methanol 

Relevant articles and documents

Aqueous synthesis of N,S-dialkylthiophosphoramidates: Design, optimisation and application to library construction and antileishmanial testing

We recently reported the use of PSCl3 for the thiophosphorylation of alkylamines where the resulting N-thiophosphoramidate ions could be readily S-alkylated (Chem. Commun., 2011, 47, 6156-6158.). Herein we report the development of this methodology using amino acid, amino sugar, aminonucleoside and aniline substrates. The hydrolysis properties of N-thiophosphoramidate ions and their reactivities towards alkylating agents are also explored. In addition, we demonstrate the application of our approach to the preparation of a small library of compounds, including quinoline-based N,S-dialkylthiophosphoramidates which were tested for antileishmanial activity.