1429012-29-2

Upstream product

• 1429012-11-2 N′-(3-cyano-5-phenyl-4-(trimethylsilyl)thiophen-2-yl)-N,N-dimethylformimidamide 
• 1429012-17-8 N′-(3-cyano-4-iodo-5-phenylthiophen-2-yl)-N,N-dimethylformimidamide 
• 1429012-19-0 N′-(3-cyano-5-phenyl-4-(phenylethynyl)thiophen-2-yl)-N,N-dimethylformimidamide 

Relevant academic research and scientific papers

Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase - Parallel synthesis of analogs via a trimethylsilyl ylidene intermediate

Thienopyrimidine-based bisphosphonates were identified as a new class of nitrogen-containing bisphosphonate (N-BP) inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Analogs were prepared via cyclization of 2-(1-(trimethylsilyl)ethylidene)malononitrile to 2-amino-4-(trimethylsilyl) thiophene-3-carbonitrile in the presence of elemental sulfur. Direct ipso-iododesilylation of this intermediate led to selective iodination at C β of the sulfur atom in high efficiency. The synthetic protocols developed were used in the parallel synthesis of structurally diverse thieno[2,3-d]pyrimidin-4-amine-based bisphosphonate inhibitors of hFPPS.