1429129-75-8Relevant academic research and scientific papers
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands
, p. 3217 - 3227 (2013)
The bromodomain protein module, which binds to acetylated lysine, is emerging as an important epigenetic therapeutic target. We report the structure-guided optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodom
