1429192-14-2

Basic information

• Product Name: 2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
• Synonyms: 2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
• CAS NO: 1429192-14-2
• Molecular Weight: 403.528
• Mol File: 1429192-14-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one(1429192-14-2)
• EPA Substance Registry System: 2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one(1429192-14-2)

Safety Data

• Hazardous Substances Data: 1429192-14-2(Hazardous Substances Data)

Upstream product

• 4424-17-3 2-aminobenzanilide 
• 499770-66-0 5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxaldehyde 

Downstream Products

• 1429192-72-2 1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

N -Methyldihydroquinazolinone derivatives of retro-2 with enhanced efficacy against shiga toxin

The Retro-2 molecule protects cells against Shiga toxins by specifically blocking retrograde transport from early endosomes to the trans-Golgi network. A SAR study has been carried out to identify more potent compounds. Cyclization and modifications of Retro-2 led to a compound with roughly 100-fold improvement of the EC50 against Shiga toxin cytotoxicity measured in a cell protein synthesis assay. We also demonstrated that only one enantiomer of the dihydroquinazolinone reported herein is bioactive.