14292-44-5Relevant articles and documents
Novel cyclized Pifithrin-α p53 inactivators: Synthesis and biological studies
Pietrancosta, Nicolas,Maina, Flavio,Dono, Rosanna,Moumen, Anice,Garino, Cedrik,Laras, Younes,Burlet, Stephane,Quelever, Gilles,Kraus, Jean-Louis
, p. 1561 - 1564 (2005)
Starting from various cyclic or bicyclic ketones, we have synthesized novel Pifithrin-α analogues bearing different methyl substituted phenyl ketone groups at the N3-position of the 2-iminothiazole heterocycle. From stability studies in a biolo
A novel and efficient one pot synthesis of 2,4-disubstituted thiazoles and oxazoles using phenyltrimethylammoniumtribromide in ionic liquid
Muthyala, Manoj Kumar,Kumar, Anil
, p. 959 - 964 (2012/10/29)
A novel and efficient one-pot procedure has been described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammoniumtribromide as in situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, respectively in [bmim][BF4] ionicliquid. The advantages of the procedure include avoiding the handling of lacrymetric compounds, hazardous and toxic organic solvents along with good to excellent yield of the products.