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5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE, also known as thiazole, is a heterocyclic organic compound with a seven-membered ring containing a thiazole ring system. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and pharmacological properties.

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  • 14292-44-5 Structure
  • Basic information

    1. Product Name: 5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE
    2. Synonyms: 4H-cyclohepta[d]thiazol-2-amine, 5,6,7,8-tetrahydro-;5,6,7,8-tetrahydro-4H-cyclohepta[d][1,3]thiazol-2-amine(SALTDATA: FREE)
    3. CAS NO:14292-44-5
    4. Molecular Formula: C8H12N2S
    5. Molecular Weight: 168.26
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 14292-44-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 330.7 °C at 760 mmHg
    3. Flash Point: 153℃
    4. Appearance: /
    5. Density: 1.21 g/cm3
    6. Vapor Pressure: 0.000163mmHg at 25°C
    7. Refractive Index: 1.612
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE(14292-44-5)
    12. EPA Substance Registry System: 5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE(14292-44-5)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 14292-44-5(Hazardous Substances Data)

14292-44-5 Usage

Uses

Used in Pharmaceutical Industry:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as a building block for the synthesis of various pharmaceuticals for its versatile reactivity and pharmacological properties.
Used in Agrochemical Industry:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as a building block for the synthesis of agrochemicals for its versatile reactivity and pharmacological properties.
Used in Antibacterial Applications:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as an antibacterial agent for its potential to inhibit bacterial growth.
Used in Antifungal Applications:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as an antifungal agent for its potential to inhibit fungal growth.
Used in Anti-inflammatory Applications:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as an anti-inflammatory agent for its potential to reduce inflammation.
Used in Antiviral Applications:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as an antiviral agent for its potential to inhibit viral replication.
Used in Anticancer Applications:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as an anticancer agent for its potential to inhibit cancer cell growth.
Used in Dye and Pigment Industry:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used in the production of dyes and pigments for its color properties.
Used in Rubber Chemical Industry:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used in the production of rubber chemicals for its chemical properties.
Used in Fluorescence Sensor Applications:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used as a fluorescence sensor for its potential to detect specific molecules or ions.
Used in Materials Science:
5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[D][1,3]THIAZOL-2-AMINE is used in materials science for its potential application in the development of new materials with unique properties.

Check Digit Verification of cas no

The CAS Registry Mumber 14292-44-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,9 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14292-44:
(7*1)+(6*4)+(5*2)+(4*9)+(3*2)+(2*4)+(1*4)=95
95 % 10 = 5
So 14292-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2S/c9-8-10-6-4-2-1-3-5-7(6)11-8/h1-5H2,(H2,9,10)

14292-44-5 Well-known Company Product Price

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  • Aldrich

  • (CBR00338)  5,6,7,8-Tetrahydro-4H-cyclohepta[d][1,3]thiazol-2-amine  AldrichCPR

  • 14292-44-5

  • CBR00338-1G

  • 2,901.60CNY

  • Detail

14292-44-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6,7,8-tetrahydro-4H-cyclohepta[d][1,3]thiazol-2-amine

1.2 Other means of identification

Product number -
Other names 5,6,7,8-Tetrahydro-4H-cycloheptathiazol-2-ylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14292-44-5 SDS

14292-44-5Downstream Products

14292-44-5Relevant articles and documents

Novel cyclized Pifithrin-α p53 inactivators: Synthesis and biological studies

Pietrancosta, Nicolas,Maina, Flavio,Dono, Rosanna,Moumen, Anice,Garino, Cedrik,Laras, Younes,Burlet, Stephane,Quelever, Gilles,Kraus, Jean-Louis

, p. 1561 - 1564 (2005)

Starting from various cyclic or bicyclic ketones, we have synthesized novel Pifithrin-α analogues bearing different methyl substituted phenyl ketone groups at the N3-position of the 2-iminothiazole heterocycle. From stability studies in a biolo

Discovery of imidazo[2,1- b ]thiazole HCV NS4B inhibitors exhibiting synergistic effect with other direct-acting antiviral agents

Wang, Ning-Yu,Xu, Ying,Zuo, Wei-Qiong,Xiao, Kun-Jie,Liu, Li,Zeng, Xiu-Xiu,You, Xin-Yu,Zhang, Li-Dan,Gao, Chao,Liu, Zhi-Hao,Ye, Ting-Hong,Xia, Yong,Xiong, Ying,Song, Xue-Jiao,Lei, Qian,Peng, Cui-Ting,Tang, Hong,Yang, Sheng-Yong,Wei, Yu-Quan,Yu, Luo-Ting

, p. 2764 - 2778 (2015/04/14)

The design, synthesis, and SAR studies of novel inhibitors of HCV NS4B based on the imidazo[2,1-b]thiazole scaffold were described. Optimization of potency with respect to genotype 1b resulted in the discovery of two potent leads 26f (EC50 = 16

A novel and efficient one pot synthesis of 2,4-disubstituted thiazoles and oxazoles using phenyltrimethylammoniumtribromide in ionic liquid

Muthyala, Manoj Kumar,Kumar, Anil

, p. 959 - 964 (2012/10/29)

A novel and efficient one-pot procedure has been described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammoniumtribromide as in situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, respectively in [bmim][BF4] ionicliquid. The advantages of the procedure include avoiding the handling of lacrymetric compounds, hazardous and toxic organic solvents along with good to excellent yield of the products.

Discovery and hit-to-lead optimization of novel allosteric glucokinase activators

Lang, Martin,Seifert, Markus H.-J.,Wolf, Kristina K.,Aschenbrenner, Andrea,Baumgartner, Roland,Wieber, Tanja,Trentinaglia, Viola,Blisse, Marcus,Tajima, Nobumitsu,Yamashita, Tokuyuki,Vitt, Daniel,Noda, Hitoshi

supporting information; scheme or table, p. 5417 - 5422 (2011/10/12)

We report on a hit generation and hit-to-lead program of a novel class of glucokinase activators (GKAs). Hit compounds, activators at low glucose concentration only were identified by vHTS. Scaffold modification reliably afforded activators also at high s

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