1429219-53-3Relevant academic research and scientific papers
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors
Gavara, Laurent,Suchaud, Virginie,Nauton, Lionel,Théry, Vincent,Anizon, Fabrice,Moreau, Pascale
, p. 2298 - 2301 (2013)
The synthesis and Pim kinase inhibition potency of a new series of pyrrolo[2,3-g]indazole derivatives is described. The results obtained in this preliminary structure-activity relationship study pointed out that sub-micromolar Pim-1 and Pim-3 inhibitory potencies could be obtained in this series, more particularly for compounds 10 and 20, showing that pyrrolo[2,3-g]indazole scaffold could be used for the development of new potent Pim kinase inhibitors. Molecular modeling experiments were also performed to study the binding mode of these compounds in Pim-3 ATP-binding pocket.
