1429297-30-2

Basic information

• Product Name: C₂₄H₂₃Cl₂FN₄O₄
• CAS NO: 1429297-30-2
• Molecular Weight: 521.375
• Mol File: 1429297-30-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₃Cl₂FN₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₃Cl₂FN₄O₄(1429297-30-2)
• EPA Substance Registry System: C₂₄H₂₃Cl₂FN₄O₄(1429297-30-2)

Safety Data

• Hazardous Substances Data: 1429297-30-2(Hazardous Substances Data)

Upstream product

• 1429297-51-7 C₁₅H₁₅NO₄ 
• 52023-68-4 6-(morpholin-4-yl)pyridin-3-amine 
• 1429297-49-3 C₁₅H₁₂Cl₂FNO₄ 
• 1429297-50-6 C₁₆H₁₄Cl₂FNO₄ 
• 142063-12-5 methyl 5-hydroxy-2-methoxypyridinecarboxylate 

Downstream Products

• 1429297-07-3 C₂₃H₂₁Cl₂FN₄O₄ 

Relevant articles and documents

Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors

A series of novel 5-(benzyloxy)pyridin-2(1H)-ones were designed, synthesized and biologically evaluated for c-Met inhibition. Various amides and benzoimidazoles at C-3 position were investigated. A potent compound 12b with a c-Met IC50 of 12 nM was identified. This compound exhibited potent inhibition of EBC-1 cell associated with c-Met constitutive activation and showed high selectivity for c-Met than other tested 11 kinases. The binding model 12b with c-Met was disclosed by docking analysis.