14293-09-5Relevant academic research and scientific papers
A novel convergent method for the synthesis of α-acyl-γ- hydroxylactams and its application in the total synthesis of PI-090 and 091
Uchiro, Hiromi,Shionozaki, Nobuhiro,Kobayakawa, Yu,Nakagawa, Hiroko,Makino, Kimiko
, p. 4765 - 4768 (2012/08/07)
A novel convergent method for the synthesis of α-acyl-γ- hydroxylactams utilizing the aldol reaction of N-Boc-protected γ-methoxylactams was developed. As the first application of this method for the synthesis of biologically active natural products, the total synthesis of platelet aggregation inhibitors PI-090 and PI-091 were also investigated and successfully achieved.
