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1429306-18-2

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1429306-18-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1429306-18-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,9,3,0 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1429306-18:
(9*1)+(8*4)+(7*2)+(6*9)+(5*3)+(4*0)+(3*6)+(2*1)+(1*8)=152
152 % 10 = 2
So 1429306-18-2 is a valid CAS Registry Number.

1429306-18-2Downstream Products

1429306-18-2Relevant articles and documents

Synthesis of valganciclovir hydrochloride congeners

Babu, K. Srihari,Rao, M. Raghavendar,Goverdhan,Srinivas,Reddy, P. Pratap,Venkateswarlu,Anand, R. Vijaya

, p. 1751 - 1758 (2013/05/22)

Valganciclovir hydrochloride (1) is used for the treatment of cytomegalovirus (CMV) retinitis in patients with weakened immune systems. Valganciclovir hydrochloride is a hydrochloride salt of L-valyl ester of ganciclovir (2) that exists as a mixture of two diastereomers. According to the U.S. Food and Drug Administration specifications, the diastereomeric ratio of valganciclovir hydrochloride 1 should be maintained in the range 55:45 to 45:55. According to the U.S. Food and Drug Administration specifications, the diastereomeric ratio of valganciclovir hydrochloride 1 should be maintained in the range 55:45 to 45:55. During the process development of valganciclovir hydrochloride, six related substances (impurities) were observed along with the final active pharmaceutical ingredient. Among these six impurities, ganciclovir (2) and guanine (3) are the key starting materials and degraded impurities of ganciclovir, respectively. The remaining four impurities were identified as isovalganciclovir hydrochloride (4), methoxymethylguanine (5), O-acetoxy ganciclovir (6), and isovalarylganciclovir (7). The present work describes the synthesis and characterization of these four impurities.

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