1429323-77-2Relevant academic research and scientific papers
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach
Dwyer, Michael P.,Keertikar, Kartik,Paruch, Kamil,Alvarez, Carmen,Labroli, Marc,Poker, Cory,Fischmann, Thierry O.,Mayer-Ezell, Rosemary,Bond, Richard,Wang, Yan,Azevedo, Rita,Guzi, Timothy J.
, p. 6178 - 6182 (2013)
The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a] pyrimidine-derived hit 5 to the identification of a series of potent, pan-Pim inhibitors such as 11j are described.
MACROCYCLIC LRRK2 KINASE INHIBITORS
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, (2013/04/13)
The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease
