1429398-18-4

Basic information

• Product Name: C₄₇H₆₂N₂O₁₃S
• Synonyms: C₄₇H₆₂N₂O₁₃S
• CAS NO: 1429398-18-4
• Molecular Weight: 895.081
• Mol File: 1429398-18-4.mol

Chemical Properties

• CAS DataBase Reference: C₄₇H₆₂N₂O₁₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₇H₆₂N₂O₁₃S(1429398-18-4)
• EPA Substance Registry System: C₄₇H₆₂N₂O₁₃S(1429398-18-4)

Safety Data

• Hazardous Substances Data: 1429398-18-4(Hazardous Substances Data)

Upstream product

• 1422364-30-4 C₃₅H₆₀N₂O₁₁ 
• 1422364-31-5 C₃₆H₅₈N₂O₁₂ 
• 561327-05-7 C₃₄H₆₀N₂O₁₂ 
• 756821-72-4 2',4-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-(1-ethoxycyclohexyl)oxime 
• 31161-46-3 2-benzoyl-5-bromothiophene 
• 1422364-32-6 C₃₆H₅₆N₂O₁₂ 
• 561327-03-5 (E)-5-O-desosaminyl-6-O-methylerythronolide A 9-oxime 

Downstream Products

• 1422364-39-3 C₄₅H₆₀N₂O₁₂S 

Relevant articles and documents

Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides

A series of 9-O-(3-aryl-2-propargyl)oxime ketolides 8 was synthesized and evaluated for in vitro antibacterial activity. Among 8, 8b-8d, and 8h-8l displayed dramatically improved potency against inducibly MLS B-resistant and efflux-resistant pathogens as compared to clarithromycin and azithromycin. Especially, 8i (Ar4-isoquinolyl) possessed an MIC of 0.064 μg/mL against constitutively MLSB-resistant Streptococcus pneumoniae, and MICs of 0.032-0.064 μg/mL against methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus hominis. The analog 10 with a propyl linker was less effective than both the corresponding 8 and 9 containing propynyl and propenyl linkers. A docking study was performed to gain insight into the binding mode of series 8 and 9 and to rationalize the disparity found in the SAR of 8 and 9.