1429402-65-2Relevant academic research and scientific papers
Synthesis of Sulfoximidoyl-Containing Hypervalent Iodine(III) Reagents and Their Use in Transition-Metal-Free Sulfoximidations of Alkynes
Wang, Han,Cheng, Ying,Becker, Peter,Raabe, Gerhard,Bolm, Carsten
, p. 12655 - 12658 (2016/10/31)
Well-defined hypervalent iodine(III) reagents incorporating transferable sulfoximidoyl groups were obtained through ligand exchange reactions of methoxy(tosyloxy)iodobenzene (MTIB) with NH sulfoximines in good to excellent yields. The solid-state structure of a representative product was characterized by X-ray crystallography. Utilizing these reagents in synthesis provides a new, transition-metal-free approach towards N-alkynylated sulfoximines.
Copper-catalyzed N-alkynylations of sulfoximines with bromoacetylenes
Chen, Xiao Yun,Wang, Long,Frings, Marcus,Bolm, Carsten
supporting information, p. 3796 - 3799 (2014/08/05)
N-Alkynylated sulfoximines have been obtained by copper-catalyzed cross-coupling reactions starting from NH-sulfoximines and bromoacetylenes in moderate to good yields. The reaction conditions are mild, and the substrate scope is wide.
Copper-catalyzed oxidative cross-coupling of sulfoximines and alkynes
Wang, Long,Huang, He,Priebbenow, Daniel L.,Pan, Fang-Fang,Bolm, Carsten
supporting information, p. 3478 - 3480 (2013/04/24)
A 'Cu'te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines.
Exploring the reactivity of N-alkynylated sulfoximines: [2 + 2]-cycloadditions
Pirwerdjan, Ramona,Priebbenow, Daniel L.,Becker, Peter,Lamers, Philip,Bolm, Carsten
supporting information, p. 5397 - 5399 (2013/11/19)
To assess the potential of N-alkynylated sulfoximines as new (chiral) reagents for organic synthesis, their reactivity profile in numerous synthetic processes is under investigation. When reacted with ketenes, the alkynylated-sulfoximines undergo a [2 + 2]-cycloaddition process to afford sulfoximine-functionalized cyclobutenones in excellent yields.
