1429427-78-0

Basic information

• Product Name: (E)-4-(2,4-diisopropylphenyl)-4-oxo-2-butenoic acid (4-isopropylphenyl)amide
• CAS NO: 1429427-78-0
• Molecular Weight: 377.527
• Mol File: 1429427-78-0.mol

Chemical Properties

• CAS DataBase Reference: (E)-4-(2,4-diisopropylphenyl)-4-oxo-2-butenoic acid (4-isopropylphenyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(2,4-diisopropylphenyl)-4-oxo-2-butenoic acid (4-isopropylphenyl)amide(1429427-78-0)
• EPA Substance Registry System: (E)-4-(2,4-diisopropylphenyl)-4-oxo-2-butenoic acid (4-isopropylphenyl)amide(1429427-78-0)

Safety Data

• Hazardous Substances Data: 1429427-78-0(Hazardous Substances Data)

Upstream product

• 99-88-7 4-Isopropylaniline 
• 99-62-7 1,3-diisopropylbenzene 

Downstream Products

• 1615217-48-5 4-(2,4-diisopropylphenyl)-N-(4-isopropylphenyl)-4-oxo-2-(1-piperidinyl)butanamide 
• 1615217-49-6 4-(2,4-diisopropylphenyl)-N-(4-isopropylphenyl)-4-oxo-2-(1-imidazolyl)butanamide 
• 1615217-50-9 4-(2,4-diisopropylphenyl)-N-(4-isopropylphenyl)-4-oxo-2-(4-morpholinyl)butanamide 
• 1615217-51-0 4-(2,4-diisopropylphenyl)-N-(4-isopropylphenyl)-4-oxo-2-[1-(4-methyl-piperazinyl)]butanamide 

Relevant articles and documents

Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations

Congeneric set of thirty-eight 4-aryl-4-oxo-2-(N-aryl/cycloalkyl) butanamides has been designed, synthesized and evaluated for acetyl- and butyrylcholinesterase inhibitory activity. Structural variations included cycloalkylamino group attached to C2 posit

(E)-4-Aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization

Antiproliferative activity of twenty-nine (E)-4-aryl-4-oxo-2-butenoic acid amides against three human tumor cell lines (HeLa, FemX, and K562) is reported. Compounds showed antiproliferative activity in one-digit micromolar to submicromolar concentrations.