1429434-50-3Relevant academic research and scientific papers
2 - Substituted cephem compound-containing pharmaceutical composition
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, (2018/10/03)
PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.
CEPHEM COMPOUND
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, (2015/12/23)
A compound of the formula: wherein, W is —CH2? etc.; U is —S? etc.; R1 is substituted or unsubstituted carbocyclyl etc.; R2A and R2B is a) or b) described in the specification; R3 is a hydrogen atom etc.; R11 is carboxylate anion (—COO?) etc.; L is substituted or unsubstituted lower alkylene etc., E is a substituted or unsubstituted divalent group containing quaternary ammonium ion; G is a single bond etc.; D is —C(═O)—C(═O)—NR6— etc.; R10 1) to 3) described in specification; or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.
2 SUBSTITUTED CEPHEM COMPOUNDS
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, (2014/05/24)
The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.
CEPHEM DERIVATIVE HAVING CATECHOL GROUP
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, (2014/09/29)
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof wherein A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represents a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom.
