1429478-69-2Relevant articles and documents
Regiodivergent C?H and Decarboxylative C?C Alkylation by Ruthenium Catalysis: ortho versus meta Position-Selectivity
Ackermann, Lutz,Korvorapun, Korkit,Messinis, Antonis M.,Moselage, Marc,Rogge, Torben,Struwe, Julia
supporting information, p. 18795 - 18803 (2020/08/27)
Ruthenium(II)biscarboxylate complexes enabled the selective alkylation of C?H and C?C bonds at the ortho- or meta-position. ortho-C?H Alkylations were achieved with 4-, 5- as well as 6-membered halocycloalkanes. Furthermore, the judicious choice of the directing group allowed for a full control of ortho-/meta-selectivities. Detailed mechanistic studies by experiment and computation were performed and provided strong support for an oxidative addition/reductive elimination process for ortho-alkylations, while a homolytic C?X cleavage was operative for the meta-selective transformations.