1429481-10-6Relevant articles and documents
Total synthesis of (-)-cinatrin C1 based on an In(OTf) 3-catalyzed Conia-ene reaction
Urabe, Fumiya,Nagashima, Shunsuke,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi
, p. 3847 - 3857 (2013/06/05)
The stereocontrolled total synthesis of (-)-cinatrin C1, a phospholipase A2 inhibitor, has been accomplished. The key feature includes the stereoselective construction of the highly substituted tetrahydrofuran core by In(OTf)3-catalyzed Conia-ene reaction of the oxygen-tethered acetylenic malonic ester followed by dihydroxylation with concomitant lactonization.