1429615-69-9Relevant academic research and scientific papers
Tuning nanopore formation of oligocholate macrocycles by carboxylic acid dimerization in lipid membranes
Widanapathirana, Lakmini,Zhao, Yan
, p. 4610 - 4614 (2013)
Oligocholate macrocycles self-assemble into transmembrane nanopores by the associative interactions of water molecules inside the amphiphilic macrocycles. Macrocycles functionalized with a terephthalic acid side chain displayed significantly higher transport activity for glucose across lipid bilayers than the corresponding methyl ester derivative. Changing the 1,4-substitution of the dicarboxylic acid to 1,3-substitution lowered the activity. Combining the hydrophobic interactions and the hydrogen-bond-based carboxylic acid dimerization was an effective strategy to tune the structure and activity of self-assembled nanopores in lipid membranes.
