1429619-10-2Relevant academic research and scientific papers
Highly stereoselective synthesis of trisubstituted cyclohexanols using a guanidine-catalyzed tandem Henry-Michael reaction
Dai, Qipu,Huang, Huicai,Cong-Gui Zhao, John
, p. 4153 - 4157 (2013/05/22)
A highly diastereoselective (dr >99:1) and enantioselective (ee value up to 98%) synthesis of trisubstituted cyclohexanols was achieved by using a tandem Henry - Michael reaction between nitromethane and 7-oxo-hept-5-enals catalyzed by the Misaki-Sugimura guanidine.
One-pot sequential organocatalysis: Highly stereoselective synthesis of trisubstituted cyclohexanols
Dai, Qipu,Arman, Hadi,Zhao, John Cong-Gui
supporting information, p. 1666 - 1671 (2013/02/25)
A highly diastereoselective (d.r. >99:1) and enantioselective (ee value up to 96 %) synthesis of trisubstituted cyclohexanols was achieved by using a one-pot sequential organocatalysis that involved a quinidine thiourea-catalyzed tandem Henry-Michael reaction between nitromethane and 7-oxo-hept-5-en-1-als followed by a tetramethyl guanidine (TMG)-catalyzed tandem retro-Henry-Henry reaction on the reaction products of the tandem Henry-Michael reaction. Through a mechanistic study, it has also been demonstrated that similar results may also be achieved with this one-pot sequential organocatalysis by using the racemic Henry product as the substrate. Copyright
