142976-58-7Relevant academic research and scientific papers
Synthesis, Reactions and Stereochemistry of 3-Hydroxymethyl-2,3-dihydro-4H-1,3-benzoxazin-4-one and Some Perhydrogenated Derivatives
Fueloep, Ferenc,Pihlaja, Kalevi,Huber, Imre,Bernath, Gabor,Ribar, Bela,et al.
, p. 4963 - 4970 (2007/10/02)
3-Hydroxymethyl-2,3-dihydro-4H-1,3-benzoxazin-4-one and a number of its perhydrogenated derivatives were prepared from the corresponding 2-hydroxycarboxamides by treatment with a formaldehyde/formic acid mixture.Thermal decomposition of the 3-hydroxymethyl derivatives led to the previously unknown parent compounds.With one exception (14), both in the N-unsubstituted (16-18) and in the N-substituted (7-15) cyclopentane- and cyclohexane-fused derivatives the oxazinone ring predominantly attains a single half-chair conformation.
