142977-64-8 Usage
Uses
Used in Pharmaceutical Industry:
2,2-Difluoro-3-phenylpropanoic acid is used as a building block for the synthesis of various organic compounds, particularly in the pharmaceutical sector. Its unique structure allows for the development of new drugs with potential therapeutic effects, making it a valuable asset in drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical field, 2,2-Difluoro-3-phenylpropanoic acid is utilized as a starting material for the creation of novel agrochemicals. Its chemical properties may contribute to the development of more effective and environmentally friendly pesticides, herbicides, or other agricultural chemicals.
Used in Organic Synthesis:
2,2-Difluoro-3-phenylpropanoic acid is employed as an intermediate in the synthesis of complex organic molecules. Its reactivity and structural features facilitate the construction of a wide range of compounds, making it a versatile component in organic chemistry.
Used in Research and Development:
2,2-Difluoro-3-phenylpropanoic acid is used as a subject of study in research and development settings. Its potential pharmacological effects and interactions with biological systems are of interest to scientists, who may investigate its properties to uncover new applications and insights into its behavior in various contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 142977-64-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,9,7 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142977-64:
(8*1)+(7*4)+(6*2)+(5*9)+(4*7)+(3*7)+(2*6)+(1*4)=158
158 % 10 = 8
So 142977-64-8 is a valid CAS Registry Number.
142977-64-8Relevant academic research and scientific papers
A facile preparation method for α,α-difluoroalkanecarboxylic acids and esters. A formal difluoromethylene insertion to alkanecarboxylic acids using radical reaction
Okano, Takashi,Takakura, Nobuyuki,Nakano, Yuko,Okajima, Asako,Eguchi, Shoji
, p. 1903 - 1920 (2007/10/02)
Various alkyl radicals generated by the photoreaction of a series of Barton esters reacted with 1,1-dichloro-2,2-difluoroethene to give radical adducts as the major product accompanied with self-trapping products. Primary, secondary, tertiary, benzyl, and some unsaturated alkyl radicals as well as those with another functional group such as ether, carbonyl, and azide were applicable. Barton esters of diacids also afford 1:2 adducts with a small amount of 1:1 adducts and bis-self-trapping products except for the succinic case. These adducts were hydrolyzed with AgNO3/H2O-THF to α,α-difluoroalkanecarboxylic acids and methanolyzed with AgNO3/MeOH to the corresponding methyl esters. 4-Azido-2,2-difluorobutylic acid and the methyl ester were converted to difluoro-GABA and difluoro-γ-lactams.
α,α-Difluoroalkanecarboxylic acids: A general synthesis via alkyl radical addition to 1,1-dichloro-2,2-difluoroethylene
Okano,Takakura,Nakano,Eguchi
, p. 3491 - 3494 (2007/10/02)
Photodecomposition of alkanoic acid esters of N-hydroxy-2-thiopyridone with 1,1-dichloro-2,2-difluoroethylene gives alkyl-radical-trapped products, which give α,α-difluoroalkanoic acids and their methyl esters on hydrolytic or methanolytic treatment with silver nitrate.
