142979-79-1

Upstream product

• 32418-95-4 5,5-bis<<(phenylmethyl)thio>methyl>-2,4-imidazolidinedione 

Downstream Products

• 142979-84-8 5,5-bis<<<(p-carboxyphenyl)methyl>thio>methyl>-2,4-imidazolidinedione 
• 142979-81-5 5,5-bis<<<(p-bromophenyl)methyl>thio>methyl>-2,4-imidazolidinedione 
• 142979-82-6 5,5-bis<<<(p-methoxyphenyl)methyl>thio>methyl>-2,4-imidazolidinedione 
• 142979-98-4 5-<<(phenylmethyl)thio>methyl>-5-<<(2-hydroxyethyl)thio>methyl>-2,4-imidazolidinedione 
• 142979-86-0 5,5-bis<<<(p-nitrophenyl)methyl>thio>methyl>-2,4-imidazolidinedione 
• 142979-90-6 5,5-bis<<(1-naphthylmethyl)thio>methyl>-2,4-imidazolidinedione 
• 142979-83-7 5,5-bis<<<(p-cyanophenyl)methyl>thio>methyl>-2,4-imidazolidinedione 
• 142979-93-9 5,5-bis<(benzoylthio)methyl>-2,4-imidazolidinedione 
• 142979-97-3 5-<(benzylthio)methyl>-5-(mercaptomethyl)-2,4-imidazolidinedione 
• 142979-88-2 5,5-bis<<(3-pyridylmethyl)thio>methyl>-2,4-imidazolidinedione 
• 142979-89-3 5,5-bis<<(2-pyridylmethyl)thio>methyl>-2,4-imidazolidinedione 
• 142979-87-1 5,5-bis<<(4-pyridylmethyl)thio>methyl>-2,4-imidazolidinedione 
• 142979-85-9 5,5-bis<<<methyl>thio>methyl>-2,4-imidazolidinedione 
• 142979-91-7 5,5-bis<<(2-thienylmethyl)thio>methyl>-2,4-imidazolidinedione 

Relevant academic research and scientific papers

5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity

A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone.When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 μM