1429790-83-9

Upstream product

• 1375107-47-3 4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride 
• 537033-56-0 2,3,5-trifluoro-4-formyl-bromobenzene 
• 147804-30-6 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester 
• 1181759-11-4 1,1-dimethylethyl 4-[(cyclopropylamino)methyl]-4-hydroxy-1-piperidinecarboxylate 
• 1375107-45-1 1,1-dimethylethyl-4-{[(chloroacetyl)(cyclopropyl)amino]methyl}-4-hydroxy-1-piperidine carboxylate 
• 1375107-46-2 1,1-dimethylethyl 4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate 

Relevant academic research and scientific papers

FATTY ACID SYNTHASE INHIBITORS

This invention relates to novel spirocyclic piperidines according to Formula (I) which are inhibitors of fatty acid synthase (FAS), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.

FATTY ACID SYNTHASE INHIBITORS

Disclosed are compounds having Formula (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R8a, R9 Y, and m are defined herein and methods of using the same.