142980-72-1Relevant academic research and scientific papers
Highly Stereoselective Reduction of β-Keto Amides: The First General and Efficient Approach to N-mono- and non-Substituted anti-α-Alkyl β-Hydroxy Amides
Bartoli, Giuseppe,Bosco, Marcella,Marcantoni, Enrico,Melchiorre, Paolo,Rinaldi, Samuele,Sambri, Letizia
, p. 73 - 76 (2004)
The first general protocol for the anti-selective reduction of α-alkyl-β-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-α-substituted β-hydroxy amides in good yields and with high diastereo-selectivity.
