1429868-55-2

Basic information

• Product Name: C₂₉H₃₀ClF₃N₈OS
• Synonyms: C₂₉H₃₀ClF₃N₈OS
• CAS NO: 1429868-55-2
• Molecular Weight: 631.124
• Mol File: 1429868-55-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₀ClF₃N₈OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₀ClF₃N₈OS(1429868-55-2)
• EPA Substance Registry System: C₂₉H₃₀ClF₃N₈OS(1429868-55-2)

Safety Data

• Hazardous Substances Data: 1429868-55-2(Hazardous Substances Data)

Upstream product

• 302964-24-5 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide 
• 694499-26-8 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 
• 302964-08-5 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 

Relevant articles and documents

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors

We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping strategy. These synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I mutant. Compound 7u showed very potent kinase inhibitory activities against Bcr-Abl WT, Bcr-Abl E255K, Bcr-Abl Q252H, Bcr-Abl G250E and Bcr-Abl T315I, with IC50 values of 0.13 nM, 0.17 nM, 0.24 nM, 0.19 nM and 0.65 μM, respectively. This compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM, thus representing a new lead for further optimization.