1429882-39-2Relevant articles and documents
PYRROLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
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Page/Page column 36; 38, (2013/04/24)
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an active compound herein) of Formula I, IA, or IB.