1429887-45-5

Basic information

• Product Name: 5-chloro-2,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-1H-indole
• Synonyms: 5-chloro-2,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-1H-indole
• CAS NO: 1429887-45-5
• Molecular Weight: 333.839
• Mol File: 1429887-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-2,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-1H-indole(1429887-45-5)
• EPA Substance Registry System: 5-chloro-2,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-1H-indole(1429887-45-5)

Safety Data

• Hazardous Substances Data: 1429887-45-5(Hazardous Substances Data)

Upstream product

• 1351706-37-0 N-(2-iodo-4-chlorophenyl)-4-methylbenzenesulfonamide 
• 3355-28-0 1-Bromo-2-butyne 

Relevant articles and documents

Coupling and cyclization of O-iodoanilines and propargylic bromides via allenes: An efficient entry to indomethacin

A sequential allene synthesis and cyclization has been realized in a one-pot manner. A Pd(0)-catalyzed one-pot reaction of N-Ts or -Ms 2-iodoanilines and propargylic bromides afforded indoles with pharmaceutical importance highly efficiently with diversity via sequential carbon-carbon bond coupling forming allenes and azapalladation. With this newly established methodology, an efficient approach to indomethacin, an anti-inflammatory drug (NSAID), has been accomplished.